|
KMID : 1161420180210060568
|
|
Journal of Medicinal Food
2018 Volume.21 No. 6 p.568 ~ p.574
|
|
|
Effect of Irvingia gabonensis on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion
|
|
Villar Miriam Mendez-del
Gonzalez-Ortiz Manuel
Martinez-Abundis Esperanza
Perez-Rubio Karina G.
Cortez-Navarrete Marisol
|
|
|
Abstract
|
|
|
|
The aim of this study was to evaluate the effect of Irvingia gabonensis on metabolic syndrome (MetS), insulin sensitivity, and insulin secretion. A randomized, double-blind, placebo-controlled clinical trial was performed in 24 patients with MetS in accordance with the International Diabetes Federation criteria. Twelve patients received I. gabonensis (150?mg) twice a day during 90 days, and 12 patients received placebo. Glucose and insulin concentrations were measured during a 2-h oral glucose tolerance test. Also, lipid profile, creatinine, uric acid, and hepatic enzymes were determined. The area under the curve (AUC) of glucose and insulin, total insulin secretion, first phase of insulin secretion, and insulin sensitivity were calculated. Data were tested using non-parametric tests. The Ethics Committee approved the protocol. After I. gabonensis administration, significant decreases in waist circumference (WC) (94.0?±?8.0 vs. 91.0?±?8.2?cm, P?
|
|
|
KEYWORD
|
|
|
African mango, insulin resistance, insulin secretion, insulin sensitivity, metabolic syndrome
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|